TRANSLATIONAL PHYSIOLOGY Cardiac-specific genetic inhibition of nuclear factor- B prevents right ventricular hypertrophy induced by monocrotaline
نویسندگان
چکیده
Cardiac-specific genetic inhibition of nuclear factorB prevents right ventricular hypertrophy induced by monocrotaline Sandeep Kumar,* Chuanyu Wei,* Candice M. Thomas, Il-Kwon Kim, Rachid Seqqat, Rajesh Kumar, Kenneth M. Baker, W. Keith Jones, and Sudhiranjan Gupta Division of Molecular Cardiology, Department of Medicine, College of Medicine, Texas A&M Health Science Center; Scott & White Hospital; Central Texas Veterans Health Care System, Temple, Texas; and Department of Pharmacology and Cell Biophysics, University of Cincinnati, Cincinnati, Ohio
منابع مشابه
Inhibition of nuclear factor-κB in the lungs prevents monocrotaline-induced pulmonary hypertension in mice.
Pulmonary arterial hypertension (PAH) is a devastating cardiopulmonary disorder with significant morbidity and mortality in patients with various lung and heart diseases. PAH is characterized by vascular obstruction which leads to a sustained increased pulmonary vascular resistance, vascular remodeling, and right ventricular hypertrophy and failure. Limited PAH therapies indicate that novel app...
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AIMS Inhibition of phosphodiesterase 5 (PDE5) decreases pulmonary pressure and improves symptoms in patients with pulmonary arterial hypertension. It is unclear however, whether inhibition of PDE5 can prevent myocardial remodelling during right-ventricular pressure overload. METHODS AND RESULTS Right-ventricular pressure overload was produced in male rats in a pulmonary hypertension model (mo...
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Urotensin II (UII) is a vasoactive peptide with potent cardiovascular effects through a G protein-coupled receptor. Hypoxia stimulates the secretion of UII and atrial natriuretic peptide (ANP). However, the effect of UII on hypoxia-induced cardiac hypertrophy is still controversial. The present study was conducted to determine whether human UII (hUII)-mediated ANP secretion influences hypoxia-i...
متن کاملCardiac-specific genetic inhibition of nuclear factor-κB prevents right ventricular hypertrophy induced by monocrotaline.
Uncontrolled pulmonary arterial hypertension (PAH) results in right ventricular (RV) hypertrophy (RVH), progressive RV failure, and low cardiac output leading to increased morbidity and mortality (McLaughlin VV, Archer SL, Badesch DB, Barst RJ, Farber HW, Lindner JR, Mathier MA, McGoon MD, Park MH, Rosenson RS, Rubin LJ, Tapson VF, Varga J. J Am Coll Cardiol 53: 1573-1619, 2009). Although the e...
متن کاملAttenuation of compensatory right ventricular hypertrophy and heart failure following monocrotaline-induced pulmonary vascular injury by the Na+-H+ exchange inhibitor cariporide.
Pulmonary hypertension results in compensatory right ventricular (RV) hypertrophy. We studied the role of the Na+-H+ exchange (NHE) in the latter process by determining the effect of the NHE-1 inhibitor cariporide after monocrotaline-induced pulmonary artery injury. Sprague-Dawley rats received a control or cariporide diet for 7 days, at which time they were administered either monocrotaline (6...
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